The body is the most complex machine in the world, and the only one for which you cannot get a replacement part from the manufacturer. For centuries, medicine has reached for what's available--sculpting noses from brass, borrowing skin from frogs and hearts from pigs, crafting eye parts from jet...

Drawing on her own medical experience as well as fifteen years of interviews with doctors, patients, researchers, and public health experts, O'Rourke's incisive new work speaks to an urgent subject: the epidemic scale of autoimmune disease in America (even greater with the advent of 'Long Covid')...

NATIONAL BOOK CRITICS CIRCLE NOMINEE * A NEW YORK TIMES NOTABLE BOOK OF THE YEAR * NEW YORK TIMES BEST SELLER * A grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation...

WINNER OF THE PULITZER PRIZE * A NEW YORK TIMES TOP 100 BOOK OF THE CENTURY * A NEW YORK TIMES BOOK REVIEW BEST BOOK OF THE YEAR * A TIME ALL-TIME 100 NONFICTION BOOK Updated with FOUR NEW MAJOR CHAPTERS illuminating the new developments in cancer...

NATIONAL BESTSELLER * The gripping story of Elizabeth Holmes and Theranos--one of the biggest corporate frauds in history--a tale of ambition and hubris set amid the bold promises of Silicon Valley, rigorously reported by the prize-winning journalist. With a new Afterword.

Finalist for the 2025 PEN/E.O. Wilson Literary Science Writing Award USA Today Bestseller "All in Her Head accomplishes a remarkable feat of storytelling. By combining essential medical histories about women's bodies with all the narrative...

Most people want to avoid thinking about death, but Caitlin Doughty--a twenty-something with a degree in medieval history and a flair for the macabre--took a job at a crematory, turning morbid curiosity into her life's work. Thrown into a profession of gallows humor and vivid characters (both...

A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington Post The bestselling author of Leonardo da Vinci and Steve Jobs returns with a "compelling" (The Washington Post) account of how Nobel Prize winner Jennifer Doudna...

The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize-winning author of The Emperor of All Maladies--a fascinating history of the gene and "a magisterial account of...

'...aside from the murders , Charles Cullen might have been a pretty good nurse...' The true story of the most prolific serial killer in US history, The Good Nurse is 'astunning book... that should and does bring to mind In Cold Blood' New York Times

The classic account of survivors of the sleeping-sickness during the great epidemic just after World War I--and their return to the world after decades of "sleep." *  From the distinguished neurologist and the bestselling author of The Man Who Mistook His Wife...

Shortlisted for the Royal Society Science Book Prize 2021'To compare any book to a Sacks is unfair, but this one lives up to it . . . I finished it feeling thrillingly unsettled, and wishing there was more.' James McConnachie, Sunday Times'A study of diseases that we sometimes say are 'all in the...

The secret history of the body's most fascinating organ: the gut

'Fascinating, magisterially researched, and brilliantly written.' Steve Silberman, author of Neurotribes Thirty-two days underground. No heat. No sunlight. 4 June 1938. Nathaniel Kleitman and his research student make their way down the seventy-one steps leading to the mouth of...

Based on a viral article, the gripping medical mystery story of Ron Davis, a world-class Stanford geneticist who has put his career on the line to find the cure for chronic fatigue syndrome, the disease killing his son.